Gruppo Viola

Group Leader
Dr Antonella Viola
Debora Avella
Elisa Cerutti
Javier Cibella
Rita Lucia Contento
Francesca Dionisio
Marinos Kallikourdis
Cristina Mazzon
Sara Morlacchi
Adelaida Sarukhan
Cristiana Soldani
Anna Elisa Trovato
Lucia Zanotti
Mary Wang
Interessi Scientifici
modulazione della risposta immune adattativa in condizioni fisiopatologiche:
- Signalling del calcio nell’attivazione dei linfociti T in vitro e nel microambiente linfonodale
- Ruolo dell'agrina nell'attivazione e migrazione dei linfociti T
- Meccanismi di immunosoppressione operati dalle cellule T regolatrici
- Caratterizzazione della capacità immunomodulatorie di Cellule Staminali Mesenchimali
- Il ruolo del recettore chemochinico CXCR4 nella malattia di WHIM
- I linfociti infiltranti i tumori
Attività Clinico/Assistenziale
Isto-patologia e immunoistochimica
Modelli in vivo di infiammazione antigene-specifica
Saggi di attivazione in vitro di cellule T (umane e murine)
Pubblicazioni caratterizzanti
V. Bronte, T. Kasic, G. Gri, K. Gallana, G. Borsellino, I. Marigo, L. Battistini, M. Iafrate, T. Prayer-Galetti, F. Pagano and A. Viola. 2005. Boosting anti-tumor responses of T lymphocytes infiltrating human prostate cancers. The Journal of Experimental Medicine, 201:1257-68.
B. Molon, G. Gri, M. Bettella, C. Goumez-Mouton, A. Lanzavechia, C. Martinez-A, S. Manes and A. Viola. 2005. T cell costimulation by chemokine receptors. Nature Immunology, 6:465-71 .
R. Tavano, R.L. Contento, S.J. Baranda, M. Soligo, L. Tuosto, S. Manes and A. Viola. 2006. CD28 interaction with filamin-A controls lipid raft accumulation at the T cell immunological synapse. Nature Cell Biology, 8:1270-1276
R.L. Contento, B. Molon, C. Boularan, T. Pozzan, S. Manes, S. Marullo and A. Viola. 2008. CXCR4-CCR5: a couple modulating T-cell functions. Proceedings of the National Academy of Science, Jul 22;105(29):10101-6. Epub 2008 Jul 15.
Dal Secco V, Soldani C, Debrat C, Asperti-Boursin F, Donnadieu E, Viola A, Sarukhan A. 2009. Tunable chemokine production by antigen presenting dendritic cells in response to changes in regulatory T cell frequency in mouse reactive lymph nodes. PLoS One. Nov 6;4(11):e7696.
Strumentazioni disponibili
Flow cytometers FACSCanto and FACSAria; Perkin Elmer 7990HT Real-Time PCR system; Video Imaging Systems CellR IX81 (Olympus); Confocal Microscope FV1000 (Olympus), furnished with cage incubator (CO2 and temperature control) and micromanipulator (specific applications: xz stacks, FRET, photo-bleaching); Confocal Microscope FV1000 (Olympus), furnished with cage incubator (CO2 and temperature control) and the EVA modulus for TIRF; Luminescent fluorimeter; Multiphoton microscope system Trim Scope II (LaVision Biotech) with single and multi beam functionality equipped with an xyz-stage for intravital microscopy and designed to allow running of complex protocols including FLIM, FRAP, Uncaging and Photo Activation.

Usually, you might possibly n't have an excellent provide to take. You will get a good strategy associated with exactly what rolex replica sale will be excellent provides through seeking in the wrist watches your own individual currently is the owner of. They might perhaps possess a fairly poor plastic material 1, it does not necessarily research nearly because tag heuer replica sale like a individual from the phony wrist watches you can buy. In the event that this is actually the situation, then you can nicely come with an replica watches defense to buy the actual wrist watches, merely being an development. You may want to ask for exactly what another guy or even cartier replica sale wants regarding their own look at, or even whether or not these people actually enjoy it whatsoever. The point that issues probably the most whilst replicating a wristwatch may be the brilliance accomplished as well as likeness acquired towards the unique view.